The story of Saint Seiya, Knights of the Zodiac: The Sanctuary is faithful to the Gold Saint Saga episodes of the original anime TV series where Seiya the Pegasus Saint, Shiryu the Dragon Saint, Shun the Andromeda Saint, Hyoga the Cygnus Saint and Ikki the Phoenix Saint take on the task of protecting and helping the Goddess Athena destroy the 200 year Evil. Fans will be able to play as any one of the 17 characters in the game, including the 12 Knights of the Zodiac from the series, and do battle with challenging opponents through the 12 destructible battle stages, each aligned with a sign of the zodiac. Key to winning one-on-one fights is judicious burning of Cosmo energy, an element which is central to the Saint Seiya universe.