This volume contains the proceedings of the Tenth International Conference on p-adic and Non-Archimedean Analysis, held at Michigan State University in East Lansing, Michigan, on June 30-July 3, 2008. This volume also contains a kaleidoscope of papers based on several of the more important talks presented at the meeting. It provides a cutting-edge connection to some of the most important recent developments in the field. Through a combination of survey papers, research articles, and extensive references to earlier work, this volume allows the reader to quickly gain an overview of current activity in the field and become acquainted with many of the recent sub-branches of its development.