As with the two previous editions, Barile’s Clinical Toxicology: Principles and Mechanisms, Third edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. With special emphasis placed on signs and symptoms of diseases and pathology caused by toxins and clinical drugs, the new edition, examines the complex interactions associated with clinical toxicological events as a result of therapeutic drug administration or chemical exposure. The new edition presents the latest, up-to-date protocols for managing various toxic ingestions, and the antidotes and treatments associated with their pathology. In addition, the effect of toxins on a limited number of body systems and drug-induced adverse drug reactions are also covered.
KEY FEATURES
• Discusses source of the drug or chemical, pharmacological and toxicological mechanisms of action, detection, identification, and treatment
• Examines the complex interactions associated with clinical toxicological events
• Emphasizes the signs and symptoms of diseases and pathology caused by toxins and clinical drugs
• Covers effect of toxins on body systems and drug-induced adverse reactions
• Offers a unique perspective for toxicology, pharmacology, pharmacy and health professions students
The target audience for this book is undergraduate and graduate toxicology students, clinical pharmacy (Pharm.D.) students, emergency medical personnel, regulatory agencies, and other related health science professionals. It satisfies an essential need for a concise yet detailed authoritative, fundamental text addressing the current principles of clinical toxicology.
Author Biography:
Frank A. Barile, PhD, is Professor in the Toxicology Division and past chairman
of the Department of Pharmaceutical Sciences, St. John’s University College of
Pharmacy and Health Sciences, New York.
Dr. Barile received his BS in Pharmacy, MS in Pharmacology, and PhD in
Toxicology at St. John’s University. After doing a postdoctoral fellowship in
Pulmonary Pediatrics at the Albert Einstein College of Medicine, Bronx, NY, he
moved to the Department of Pathology, Columbia University—St. Luke’s Roosevelt
Hospital, NY, as a research associate. In these positions, he investigated the role of
pulmonary toxicants in collagen metabolism in cultured lung cells. In 1984, he was
appointed assistant professor in the Department of Health Sciences at City University
of NY. Sixteen years later, he rejoined St. John’s University in the Department of
Pharmaceutical Sciences in the College of Pharmacy.
Dr. Barile holds memberships in several professional associations, including the
U.S. Society of Toxicology, the American Association of University Professors, the
American Association for the Advancement of Science, the American Society of
Hospital Pharmacists, New York City Pharmacists Society, New York Academy of
Sciences, and New York State Council of Health System Pharmacists. He is past
president of the In Vitro and Alternative Methods Specialty Section of the U.S.
Society of Toxicology and a former member of the Scientific Advisory Committee
for Alternative Toxicological Methods, the National Institute of Environmental
Health Sciences, U.S. National Institutes of Health (NIH). He is former editor of
Toxicology in Vitro and Journal of Pharmacological & Toxicological Methods, published
by Elsevier Ltd.
Dr. Barile is the recipient of Public Health Service research grants from the
National Institute of General Medical Sciences, the National Institutes of Health,
and grants from private foundations dedicated to alternatives to animal testing.
He has authored approximately 100 original research manuscripts, review articles,
research abstracts, and conference proceedings in peer-reviewed toxicology and biomedical
journals. He has also published several books and related chapters in the
field. He contributed original in vitro toxicology data to the international Multicenter
Evaluation for In Vitro Cytotoxicity program. He lectures regularly to pharmacy and
toxicology undergraduate and graduate students in clinical and basic pharmaceutical
and toxicological sciences and was awarded “Professor of the Year” for the College
of Pharmacy by the St. John’s University Student Government Association (2003).
Dr. Barile has served on several U.S. government advisory committees, including:
Toxicology Assessment Peer Review Committee, U.S. Environmental Protection
Agency; National Institutes of Health Review Panel, Study Section Reviewer (2013);
Scientific Advisory Committee on Alternative Toxicological Methods (SACATM,
2005–2009); National Toxicology Program (NTP) Interagency Center for the
Evaluation of Alternative Toxicological Methods, Support Contract Reviewer (2014);
U.S. Food and Drug Administration (U.S. FDA), National Center for Toxicology
Research, Systems Biology Subcommittee (2016); National Institute for Occupational
Safety and Health (NIOSH) and Oak Ridge Associated Universities, SK Profiles
Review Group (2014); U.S. Food and Drug Administration advisory committee on
alternative toxicological methods (2013); and has served as vice president of the
Dermal Toxicology Specialty Section for the Society of Toxicology (2013–2014).
Dr. Barile received the Faculty Recognition Award, American Association of
University Professors Faculty Association Award, St. John’s University, in 2003,
2004–2005, 2013–2014, and 2015–2016 and received the prestigious Public Health
Service Medallion from the director of the National Institute of Environmental
Health Sciences, Dr. Linda Birnbaum, for contributions to the Scientific Advisory
Committee for Alternative Toxicological Methods (2009).
Dr. Barile continues original research on the cytotoxic effects of therapeutic
drugs, environmental chemicals, and controlled substances on cultured mammalian
embryonic stem cells and human induced pluripotent stem cells and has dedicated
his professional life to the advancement of in vitro alternative methods to reduce,
replace and refine animal toxicology testing.
