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Cardiovascular Biology of Purines on Hardback
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Cardiovascular Biology of Purines

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Description

Following many years when a great deal of attention was directed towards the intracellular roles of purines, there is expanding interest in the field of extracellular purinergic signalling. This volume focuses on the actions of purines in cardiovascular biology, where it is clear that they play major roles in both normal and pathophysiological conditions. Activation of different purinoceptor subtypes by purines can regulate cardiac contractility and electrical activity, modulate catecholamine-mediated responses both pre- and post-junctionally, trigger and mediate ischaemic preconditioning, cause vasodilation and vasoconstriction and enhance endothelial proliferation and apoptosis as well as inhibit platelet and neutrophil function. This book covers the cardiovascular actions mediated by the major P1 and P2 subclasses of purinoceptors and emphasizes the interactions between these two signalling systems. The text covers topics ranging from molecular and cellular to systemic and clinical. It also aims to highlight how basic advances have led to the identification of novel targets for cardiovascular therapeutic developments.
Release date Australia
October 31st, 1998
Audiences
  • Postgraduate, Research & Scholarly
  • Professional & Vocational
Contributors
  • Edited by Bruce T. Liang
  • Edited by Geoffrey Burnstock
  • Edited by James G. Dobson, Jr.
  • Edited by Joel Linden
Illustrations
XI, 374 p.
Pages
374
Dimensions
156x234x22
ISBN-13
9780792383345
Product ID
3958675

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