This is a holistic treatment of the main medical disciplines. The basic sciences including most of the achievements in cell and molecular biology have been blended with pathology and clinical medicine. The subject matter covered in preclinical and clinical courses have been reduced by almost one-third without sacrificing any of the essentials of a sound medical education. This base thus represents an integrated core curriculum. Volume 4B comprises part of the quartet dealing with cell chemistry and physiology. It illustrates the extent to which the traditional distinction between biochemical and physiological processes is being obliterated by molecular biology. The revolution in cell and molecular biology is leading to core knowledge that provides an outline of the integrative and reductionist approach which is the beginning of a new era, that of the integration of learning.