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Dna Polymerases: Discovery, Characterization And Functions In Cellular Dna Transactions

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Dna Polymerases: Discovery, Characterization And Functions In Cellular Dna Transactions

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Dna Polymerases: Discovery, Characterization And Functions In Cellular Dna Transactions by Ulrich Hubscher
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Description

Maintenance of the information embedded in the genomic DNA sequence is essential for life. DNA polymerases play pivotal roles in the complex processes that maintain genetic integrity. Besides their tasks in vivo, DNA polymerases are the workhorses in numerous biotechnology applications such as the polymerase chain reaction (PCR), cDNA cloning, genome sequencing, nucleic acids-based diagnostics and in techniques to analyze ancient and otherwise damaged DNA. Moreover, some diseases are related to DNA polymerase defects, and chemotherapy through inhibition of DNA polymerases is used to fight HIV, Herpes and Hepatitis B and C infections. We have recently witnessed the discovery of an abundance of novel DNA polymerases in viruses, bacteria, archaea and eukaryotes with specialized properties whose physiological functions are only beginning to be understood. This book summarizes the current knowledge of these fascinating enzymes. It is intended for a wide audience from basic scientists, to diagnostic laboratories and to clinicians who seek a better understanding of these fascinating enzymes.
Release date Australia
April 15th, 2010
Country of Publication
Singapore
Imprint
World Scientific Publishing Co Pte Ltd
Pages
340
Dimensions
165x249x20
ISBN-13
9789814299169
Product ID
4158309

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