Non-Fiction Books:

DNA Tumor Viruses

Oncogenic Mechanisms
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Description

DNA tumor viruses have long been useful experimental models of carcinogenesis and have elucidated several important mechanisms of cell transformation. ReĀ­ search in recent years has shown that human tumors have a multifactorial nature and that some DNA tumor viruses may playa key role in their etiology. The aim of this book is to assess our knowledge of DNA tumor viruses by reviewing animal models, mechanisms of transformation, association with human tumors, and possiĀ­ bilities of prevention and control by vaccination. Animal models of tumor virology have contributed significantly to our underĀ­ standing of the epidemiology and pathogenesis of virus-induced tumors. Bovine papillomaviruses induce papillomas in the intestine of cattle. The papillomas undergo a transition to carcinomas in cows feeding on bracken fern, which proĀ­ duces a toxin with radiomimetic and immunosuppressive functions. This example of cooperation between a virus and chemical carcinogens parallels the cooperative role of human papillomaviruses (HPVs) and herpes simplex virus type 2 (HSV-2) with environmental carcinogens in the pathogenesis of cervical cancer. Likewise, hepatocarcinomas appearing in woodchucks chronically infected by woodchuck hepatitis virus (WIN) provide strong support for the relationship between hepatitis B virus (HBV) infection and human hepatocellular carcinoma. Also, the fact that WIN DNA integrates closely to cellular oncogenes suggests a possible molecular mechanism for the tumorigenesis induced by HBV.
Release date Australia
June 18th, 2013
Audience
  • Professional & Vocational
Contributors
  • Edited by Giuseppe Barbanti-Brodano
  • Edited by Herman Friedman
  • Edited by Mauro Bendinelli
Edition
Softcover reprint of the original 1st ed. 1995
Illustrations
XXIV, 428 p.
Pages
428
Dimensions
152x229x23
ISBN-13
9781489911025
Product ID
21840508

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