In this book we explore a sea change occurring in leadership for academic women in the sciences and engineering. Our approach is a two-pronged one: On the one hand, we outline the nature of the changes and their sources, both in various literatures and from program research results. On the other hand, we specify and provide detail about the persistent problems and obstacles that remain as barriers to women’s full participation in academic science and engineering, their career advancement and success, and, most important, their role as leaders in making change. At the heart of this book is our goal to give some shape to the research, practice, and programs developed by women academic leaders making institutional change in the sciences and engineering.