This book examines the university spin-off firm formation process and how this process can be facilitated within a university context. A university spin-off is defined as a new venture which is initiated in a university context and based on technology developed within a university. This book adds more theoretically grounded approaches to the spin-off literature by taking a constructivist perspective emphasizing the entrepreneurial process and the university capabilities to facilitate this process. This book emphasizes that university spin- off firms emerge as a result of complex processes involving many actors. The spin-off activity is to a large degree embedded within the other university activities and the university capabilities to facilitate this activity are based at multiple levels within and outside the university.