The South Carolina 22nd Infantry Regiment was organized and mustered into Confederate service in December, 1861. Some of its members were recruited in Oconee and Edgefield counties. After serving in South Carolina, the unit was sent to Virginia and assigned to General Evans', Elliot's, and Wallace's Brigade. It was active at Second Manassas, South Mountain, and Sharpsburg before being ordered to North Carolina and later Mississippi. The 22nd was engaged at Jackson, moved to Charleston, and in the spring of 1864 returned to Virginia. It participated in the Petersburg siege south and north of the James River and saw action around Appomattox. The unit reported 18 casualties at Secessionville, 17 at Rappahannock Station, and 84 during the Maryland Campaign. In October, 1863, it contained 360 effectives, and there were 216 killed or wounded at the Petersburg mine explosion. Many were disabled at Sayler's Creek, and on April 9, 1865, it surrendered 11 officers and 77 men. Companies Of The South Carolina 22nd Infantry Regiment. Some of the members were recruited in Oconee and Edgefield counties. Col. Rivers states that he originally recruited 873 men under Col. S. B. Goodlett [actually Spartan D. Goodlett].Co. A, from Edgefield, Capt. C. Adams; Co. B, from Spartanburg, Capt. ______; Co. C, from Spartanburg, Capt. A. Wakefield; Co. D, from Pickens, Capt. Jas. O'Connell; Co. E, from Lancaster, Capt.. M. Hilton; Co. F, from Pickens, Capt. J. M. Stewart; Co. G, from Anderson, Capt._______; Co. H, from Greenville, Capt. _______; Co. I, from Orangeburg, Capt. H. W. Millhouse; Co. K, from Pickens, Capt. M. S. Messer.