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Lead Generation Approaches in Drug Discovery



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Lead Generation Approaches in Drug Discovery by Zoran Rankovic
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This resource provides an integrated and comprehensive overview ofmodern approaches to drug lead discovery. Each chapter in this bookreviews the theoretical background and application of a keytechnology in drug discovery, complemented by relevant casestudies. The coverage includes the key approaches for drug designand discovery high-throughput screening, fragmentscreening, multi-target drugs, de novo design, ADMET, naturalproducts. This cutting-edge reference helps medicinal chemists inbiotech, pharmaceutical, and other research contexts consider allpossible avenues in starting their drug research programs.

Author Biography

ZORAN RANKOVIC is a Senior Research Fellow andAssociate Director in Medicinal Chemistry at Schering-PloughResearch Institute, UK. He received his PhD in organic chemistryfrom the University of Leeds (UK) before starting his medicinalchemistry career in 1995 at Organon, UK. Since then, working onprojects over a range of therapeutic areas, including psychosis,analgesia, and cardiovascular and bone diseases, he gainedextensive experience in all stages of the drug discovery process,including lead generation. From this work, Dr. Rankovic hasauthored or coauthored over fifty scientific publications, bookchapters, and patents, and has given invited lectures at numerousinternational conferences. RICHARD MORPHY is a medicinal chemistry section head atSchering-Plough Research Institute (SPRI) at Newhouse, Scotland. Hehas twenty years' experience in the pharmaceutical industry,previously working for Celltech and Organon on a wide range ofoncology, inflammation, psychiatry, and analgesia projects. Inaddition to his extensive experience of the lead discovery process,he has a keen interest in the development of medicinal chemistry inemerging economies and is an opinion leader in the area ofmulti-target drug discovery.
Release date Australia
April 9th, 2010
Country of Publication
United States
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