Lethal Twins is a story of law-and-order versus criminal minds in the 1950s and early 1960s. Twins Tom and Fred Mueller grew up in a middle-class neighborhood in Toledo, Ohio. They had vastly different interests and drives. Tom was a Marine in the Korean War and afterward was recruited as a federal agent helping to combat the growing drug-smuggling problem. He became attracted to a fellow agent in Washington, Sheila Bond. Fred chose an equally dangerous but extremely lucrative career in Manhattan, where he became romantically entangled with Lila Colozzi, niece of a well-connected mobster.