Men in Black 2: Alien Escape is a fast-paced third-person perspective action game liberally infused with the trademark humour of the smash 1997 movie and the upcoming sequel. The game is divided into five distinct episodes, including a Nuclear Station, the Docks and the streets of Manhattan. All episodes include various levels and challenges to complete prior to progressing through the game.

At the beginning of each level players select either Jay, the athletic, reckless fast-talker, or Kay, the confident veteran. While Jay moves at a faster pace, Kay’s knowledge of weapons gives him a higher weapon damage and health bar. Allowing players to switch between characters gives them the opportunity to experiment with various weapons and character strengths, adding variety to the gameplay. Additionally, the non-playable character partner often appears in computer-generated cut-scenes and via comlink throughout the game, providing back up, advice and, of course, wisecracks. Other key members of the Men in Black 2: Alien Escape team, like Zed, also make appearances. Adding to the mayhem is a host of new aliens featured in the upcoming movie sequel as well as popular creatures from the 1997 film, including the coffee-drinking Manitoba. While some aliens are allies and informants, most are hostile and will do anything to take over the planet.