Morphofunctional Aspects of Tumor Microcirculation

By:

Domenico Ribatti

Format:

Hardback

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Description

Blood vessels of tumors display many structural and functional abnormalities. Their unusual leakiness, potential for rapid growth and remodeling, and expression of distinctive surface molecules mediate the dissemination of tumor cells in the bloodstream and maintain the tumor microenvironment. Like normal blood vessels, they consist of endothelial cells, mural cells and their enveloping basement membrane. Common features, irrespective of their origin, size and growth pattern, are absent hierarchy, formation of large-caliber sinusoidal vessels, markedly heterogeneous density, increased permeability, decreased and abnormal pericyte-endothelial cell adhesion, irregular basement membrane structure, and the incorporation of bone-marrow-derived endothelial progenitor cells in the microvasculature. A number of specific tumor endothelial markers have been identified, as well as chromosomal abnormalities. These markers may be used to deliver drugs specifically and selectively to the tumor microvasculature.

Release date Australia

September 29th, 2012

Author

Domenico Ribatti

Audience

Professional & Vocational

Edition

2012 ed.

Illustrations

9 Tables, black and white; XII, 116 p.

Pages

116

Dimensions

155x235x13

ISBN-13

9789400749351

Product ID

20334859

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