"Murder at the Flatiron building," is a mystery that has it's beginnings in Tuscany, Italy and Guinea, South Africa, some 30-years before the mystery takes place; in 1954. Robert Randall, a student at a prestigious New York City art school, that is located in the penthouse of the Flatiron building, experiences a strange, chance meeting that catapults him into a hunt for an unknown killer. He persuades an old, New York City police detective, Frank Breen, to help him track down the killer. The pursuit takes them to a number of New York's most interesting places, to confront some of the City's most fascinating citizens. The New York City Police Department, the FBI, the Secret Service, and the U.S. Customs service, all become involved in the bringing the murderer to justice.