Dr. Rosano is Professor of Epidemiology at the University of Pittsburgh, Pittsburgh USA. Dr. Rosano's research integrates methods from the fields of neuroimaging, geriatric medicine, epidemiology and neuroscience to implement novel strategies for improving brain health and function. Her work to date has characterized and contrasted “normal” brain aging in older adults and “accelerated” brain aging in adults exposed to chronic diseases. Dr. Ikram is associate professor of Neuroepidemiology at the Erasmus University Medical Center in Rotterdam, the Netherlands. He is principal investigator of the Rotterdam Study and of the neurology core of the Rotterdam Study. His focus is on understanding the occurrence causes, pre-clinical phase and prognosis of neurological disease in late life, thereby focusing particularly on dementia and its subtypes, stroke, Parkinson's disease. Mary Ganguli, MD, MPH, FRCP(C), is Professor of Psychiatry, Neurology, and Epidemiology at the University of Pittsburgh (Pittsburgh, PA, USA). She specializes in geriatric psychiatry and psychiatric epidemiology. She has for the past 30 years conducted large-scale population studies in the USA and in India, focused on the epidemiology of cognitive impairment and dementia in older adults. She has published extensively on these topics, served on editorial boards and as associate editor for several journals, on work groups of the American Psychiatric Association and the American Academy of Neurology, and as grant reviewer for the National Institutes of Health and other funding agencies.