Newspaperman Roger Adams (Cary Grant) falls for record store worker Julie Gardiner Adams (Irene Dunne) and the pair marry on New Year's Eve, shortly before Roger leaves for a new job in Tokyo. His new wife joins him three months later and announces she is pregnant, but a major earthquake in Tokyo leads to her losing the baby and unable to bear anymore.
The pair eventually return to America where Roger buys a small country newspaper and Roger and Julie begin the process of adopting a child. When the newspaper folds it looks as though Roger and Julie will lose the child, being forced to make a heartfelt plea to the judge. The story is told in a series of flashbacks, each introduced by a piece of music from Julie¡¦s collection. Cary Grant¡¦s performance earned him an Oscar nomination for Best Actor.