Phosphoinositides I: Enzymes of Synthesis and Degradation

Name: Phosphoinositides I: Enzymes of Synthesis and Degradation
SKU: 22296544
Price: 414.99 AUD
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Paperback / softback

Series:

Subcellular Biochemistry

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Description

Phosphoinositides play a major role in cellular signaling and membrane organization. During the last three decades we have learned that enzymes turning over phosphoinositides control vital physiological processes and are involved in the initiation and progression of cancer, inflammation, neurodegenerative, cardiovascular, metabolic disease and more. In two volumes, this book elucidates the crucial mechanisms that control the dynamics of phosphoinositide conversion. Starting out from phosphatidylinositol, a chain of lipid kinases collaborates to generate the oncogenic lipid phosphatidylinositol(3,4,5)-trisphosphate. For every phosphate group added, there are specific lipid kinases – and phosphatases to remove it. Additionally, phospholipases can cleave off the inositol head group and generate poly-phosphoinositols, which act as soluble signals in the cytosol. Volume I untangles the web of these enzymes and their products, and relates them to function in health and disease. Phosphoinositide 3-kinases and 3-phosphatases have received a special focus in volume I, and recent therapeutic developments in human disease are presented along with a historical perspective illustrating the impressive progress in the field.

Release date Australia

April 16th, 2014

Audience

Professional & Vocational

Contributors

Edited by John D. York
Edited by Matthias Wymann
Edited by Tamas Balla

Illustrations

XVI, 356 p.

Pages

356

Series

Subcellular Biochemistry

Dimensions

155x235x20

ISBN-13

9789401781572

Product ID

22296544

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Phosphoinositides I: Enzymes of Synthesis and Degradation

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