Geared to residents and fellows in nephrology, internal medicine, and other specialties, this classic text bridges the gap between basic and clinical sciences for the many disorders associated with electrolyte imbalances and kidney dysfunction. This edition has been thoroughly revised by world-renowned contributors to reflect recent developments in renal pathophysiology. Highlights include completely updated information on the role of the kidney in hypertension, afferent and efferent mechanisms of renal sodium retention, and delineation of mutation defects causing congenital nephrogenic diabetes insipidus. Each chapter begins with normal function and pathophysiology and quickly moves to clinical conditions and treatment. Numerous illustrations, tables, charts, and graphs make complex subjects understandable. Up-to-date references are also included.