Gwen Stacy is back in the webs and has an all-new mystery to solve: the reappearance of the Lizard! The Spider-Woman of Earth-65 was convinced that the Lizard died along with Peter Parker. But a new reptilian rampage leaves her with doubts not only about Peter's life, but his death as well. Troubles begin to mount as the Osborns of Gwen's world make their debut, and she finds herself on S.H.I.E.L.D.'s wanted list! Perhaps some wise words from a mentor figure could help - how about Jessica Drew, the Spider-Woman of Earth-616? COLLECTS SPIDER-GWEN 1-6