An immortal battle for supremacy. For centuries, two races have evolved. Hidden deeply within human culture - the aristocratic, sophisticated Vampires, and the brutal, feral Lycans (werewolves). To humanity, their existence is no more than a whisper of a myth. But to each other, they are mortal rivals, sworn to wage a secret war until only one race is left standing. In the midst of this ongoing struggle, a Vampire warrior, Selene (Kate Beckinsale), discovers a Lycan plot, a secret that has terrifying repercussions for both tribes - a plot to awaken a new invincible species of predator that combines the strengths of both creatures and the weaknesses of neither...