Dr. Hunter S. Thompson, the legendary underground reporter whose passion for writing was second only to his love of weird chemicals, alcohol, violence and insanity. Along with best friend (Peter Boyle), Murray offers a manic look back at the Sixties and Seventies as an eyewitness to everything from a free-for-all San Francisco drug trial to a one-on-one bathroom interview with then Presidential candidate Richard Nixon.

Where the Buffalo Roam is a 1980 American semi-biographical comedy film which loosely depicts author Hunter S. Thompson's rise to fame in the 1970s and his relationship with Chicano attorney and activist Oscar Zeta Acosta. Art Linson directed the picture, while Bill Murray portrayed the author and Peter Boyle portrayed Acosta, who is referred to in the film as Carl Lazlo, Esq. A number of other names, places, and details of Thompson's life are also changed.