To plan, build, monitor, maintain, and dispose of products and assets properly, maintenance and safety requirements must be implemented and followed. A lack of maintenance and safety protocols leads to accidents and environmental disasters as well as unexpected downtime that costs businesses money and time. With the arrival of the Fourth Industrial Revolution and evolving technological tools, it is imperative that safety and maintenance practices be reexamined. Applications and Challenges of Maintenance and Safety Engineering in Industry 4.0 is a collection of innovative research that addresses safety and design for maintenance and reducing the factors that influence and degrade human performance and that provides technological advancements and emergent technologies that reduce the dependence on operator capabilities. Highlighting a wide range of topics including management analytics, internet of things (IoT), and maintenance, this book is ideally designed for engineers, software designers, technology developers, managers, safety officials, researchers, academicians, and students.