Autodesk Fusion 360 Surface Design and Sculpting with T-Spline Surfaces (5th Edition) textbook has been designed for instructor-led courses as well as self-paced learning. It is intended to help engineers and designers interested in learning Autodesk Fusion 360 for creating complex shape real-world models by using surface and T-Spline modeling techniques. This textbook is a great help for Autodesk Fusion 360 users who are new to surface and T-Spline modeling. It consists of a total of 232 pages covering the Surface and Form/Sculpt environments of Autodesk Fusion 360. It teaches users to use Autodesk Fusion 360 mechanical design software for creating complex shapes, three-dimensional surfaces and T-Spline models of zero thickness. This edition of textbook has been developed using Autodesk Fusion 360 software version: V.2.0.11685 (December 2021 Product Update). This textbook not only focuses on the usage of the tools and commands of Autodesk Fusion 360 for creating surface and T-Spline models but also on the concept of design. Every chapter in this textbook contains Tutorials followed by theoretical description, that provide users with step-by-step instructions for creating surface designs and sculpting with T-Spline surfaces. Moreover, every chapter ends with Hands-on Test Drives which allow users to experience the user friendly and powerful capacities of Autodesk Fusion 360.