Dr. Jacobson has taught neuroanatomy and gross anatomy for many years to medical and dental students at Tufts University School of Medicine, and an upper level biology course on the Central Nervous System to undergraduates at Tufts University in Medford, MA utilizing many of Dr. Marcus’ cases to engage the students. He also has used several movies on the brain developed in Hollywood to further involve  the students.   Dr. Pugsley is a senior neurosurgeon with extensive clinical and teaching experience.  He trained in Neurosurgery at Tufts University School of Medicine. He observed that the inclusion of case history materials reinforces the basic science subject matter learned by markedly increasing the interest of the students in both basic and clinical science material. He has added many new cases and a neurosurgeons’ prospective to disease.  Dr. Elliott M. Marcus, M.D. was the father of neurosciences at the Tufts University School of Medicine.With his passing in 2011, we lost a dear friend, colleague, dynamic teacher, and an outstanding neurologist. We are using in this book many of the cases he developed to teach problem solving skills to medical students, dental students, and residents in neurology and medicine as they address disease in the CNS.