The Routledge Handbook on Climate Change and Health System Sustainability takes the reader on a journey to understand the interconnectedness of human health, climate change, and healthcare systems. The book begins by exploring how climate change is affecting human health through the increasing frequency of natural disasters, such as bush fires, droughts and heatwaves, and the emergence of new infectious diseases, such as the SARS-CoV2 virus, all of which drive up demand for health services that are already heavily burdened by increasing rates of chronic diseases and ageing populations. Chapters then turn to the contribution of the healthcare system itself to climate change— explaining how current clinical practices, including wasteful care of low value, create an unsustainable carbon footprint and threaten the very viability of healthcare systems. Throughout the volume, descriptions of practical solutions and implemented case studies are used to illustrate the feasibility of taking action in the real world of the healthcare delivery ecosystem. Bringing together a mix of forward-thinking environmental and health researchers, policymakers, leaders, managers, clinicians, patients, and health industry leaders to clarify the current state and future of sustainable healthcare systems, this book will be of interest to researchers and policymakers of climate and health systems.