In this issue of Veterinary Clinics of North America: Food Animal Practice, guest editors Drs. Nial J. O'Boyle, John Dustin Loy, and Jessica L. Klabnik bring their considerable expertise to the topic of Genomics. Top experts provide a primer on fundamentals, applications, and implementation of genetics and genomics into ruminant practice, including articles on key genetics/genomics strategies and economic impact; sampling and laboratory logistics; beef and dairy genetic evaluations; and the role of veterinary practitioners in the genomic era in beef and dairy. Contains 12 relevant, practice-oriented topics including genetics and genomics 101; recessive conditions in beef and dairy cattle; European dairy cattle evaluations and international use of genomic data; discovering and developing the next generation of dairy and beef genetics; new frontiers for the future of genomics; and more. Provides in-depth clinical reviews on genomics, offering actionable insights for clinical practice. Presents the latest information on this timely, focused topic under the leadership of experienced editors in the field. Authors synthesize and distill the latest research and practice guidelines to create clinically significant, topic-based reviews.