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This book highlights current approaches and future trends in the use of mass spectrometry to characterize protein therapies. As one of the most frequently utilized analytical techniques in pharmaceutical research and development, mass spectrometry has been widely used in the characterization of protein therapeutics due to its analytical sensitivity, selectivity, and specificity. This book begins with an overview of mass spectrometry techniques as related to the analysis of protein therapeutics, structural identification strategies, quantitative approaches, followed by studies involving characterization of process related protein drug impurities/degradants, metabolites, higher order structures of protein therapeutics. Both general practitioners in pharmaceutical research and specialists in analytical sciences will benefit from this book that details step-by-step approaches and new strategies to solve challenging problems related to protein therapeutics research and development.
Author Biography
Dr. Guodong Chen has extensive pharmaceutical research experience in major pharmaceutical companies, including Eli Lilly, Schering-Plough (now Merck) and Bristol-Myers Squibb. He is currently heading a mass spectrometry group at Bristol-Myers Squibb’s Princeton site, providing mass spectrometric/analytical support to drug discovery and development programs in small molecule pharmaceuticals and biologics. He has over 45 research publications in peer-reviewed journals and 9 book chapters covering the broad area of mass spectrometry and analytical sciences. He has co-edited two books: “Characterization of Impurities and Degradants Using Mass Spectrometry” and “Mass Spectrometry of Proteins/Peptides in Drug Discovery” (respectively 2010 and forthcoming). He is a short course instructor for two short courses on “LC/MS: Theory, Instruments and Applications” and “Practical Solutions to Characterization of Protein Therapeutics Using Mass Spectrometry” at Eastern Analytical Symposium.
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