The main purpose of this research is to study and analyze the phenomenon of the influence of the strategic planning and business environment on the performance of major pharmaceutical companies in Indonesia. Following the Five force of Porter to see how the pharmaceutical industry competition, and by using the GE matrix to capture the industry attractiveness to get insight if the industry still attractive enough to be entered. Analysis was employed to examine both primary and secondary data. Primary data consisted of questionnaires distributed the top 50 pharmaceutical companies, the experts and authoritative person in the Indonesia healthcare and pharmaceutical distribution industry in the five cities. Meanwhile, secondary data were collected from internal sources and external sources.