Man's most precious treasure is his genetic heritage which guides the health and proper development of future generations. Undoubtedly, one of the most emerging branches of the medical science in the present day world is Genetics, because of its practical value in human welfare. It is now evident that there is a genetic basis for most diseases including periodontitis. Most importantly identifying specific genetic risk factor and applying genetic information and technology to the diagnosis, prevention, and therapeutic strategies of periodontitis is academically appealing and conceptually compelling, but there is an equal significant need for the clinician to maintain a realistic prospective of the clinical utility of genetic information.