The parasites that live and nourished from blood cells of the host are called hemoparasites. The two main species of Plasmodium i.e. P. vivax and P. falciparum are endemic in Pakistan. P. vivax is dominant over P. falciparum. Literature revealed that the prevalence of P. vivax in Pakistan is 74% while P. falciparum is 26% (WHO 2009). The present research estimated the intensity of Plasmodium infection in Korangi, Karachi to develop awareness and protective measures. One year data has been collected from hospitals and laboratories of Korangi Creek and examined. Total 481 infected slides were observed out of which 396 (82.3%) were P. vivax and 85 (17.6%) were P. falciparum. The infection ratio was 4.5:1. The infection % in Male is 59.25% while in female is 40.75%. The statistical analysis shows variation in mean and standard deviation of age, the mean age was 25. Infection incidence in age group 1-15 years 15.17%, in 16-40 years 81.28% and in 41-60 was 3.53%. It was concluded that incidence rate was high during the year especially of 16-40 years of age. The protective measures are required to overcome the disease. This study will benefit to students and researchers in this field.