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Metodologiya Lokus-Spetsificheskogo Analiza Metilirovaniya Dnk

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Metodologiya Lokus-Spetsificheskogo Analiza Metilirovaniya Dnk by Strel'nikov Vladimir
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Description

Metilirovanie raspredeleno na protyazhenii CpG-ostrovkov genoma cheloveka neravnomerno i modifikatsiya razlichnykh CpG-dinukleotidov po-raznomu vliyaet na ekspressiyu genov. Pravil'nyy dizayn laboratornykh protokolov dlya opredeleniya metilirovaniya DNK mozhet osnovyvat'sya tol'ko na dostovernoy informatsii o strukturno-funktsional'noy organizatsii izuchaemykh C, G-bogatykh oblastey. Na segodnyashniy den' podobnaya informatsiya otsutstvuet dlya bol'shinstva, dazhe naibolee khorosho izuchennykh, genov, vovlechyennykh v kantserogenez. V svyazi s etim osoboe znachenie priobretaet podrobnaya individual'naya kharakteristika osobennostey genomnykh lokusov, differentsial'noe metilirovanie kotorykh assotsiirovano s razvitiem zlokachestvennykh novoobrazovaniy. V monografii opisany sovremennye podkhody k vyboru genomnykh lokusov dlya analiza differentsial'nogo metilirovaniya DNK i trebovaniya k dizaynu test-sistem, prednaznachennykh dlya lokus-spetsificheskogo analiza
Release date Australia
December 29th, 2014
Country of Publication
United States
Illustrations
black & white illustrations
Imprint
LAP Lambert Academic Publishing
Pages
104
Dimensions
152x229x6
ISBN-13
9783659670411
Product ID
23701126

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