This volume examines the multidisciplinary aspects of a mission to the stars. The feasibility of a journey to the stars in a lifetime of a single human being is quite unlikely. Thus, during the conduct of a one semester course in astrobiology, undergraduate students, and some high school students, were asked to contribute to this volume. The laboratory section for the course within the Honors College of George Mason University was taught in the manner of a problem based learning pedagogy. Not only were science and engineering aspects of a multigenerational starship voyage addressed, but also the sociological and psychological aspects of such a journey to the stars were examined. We hope this volume provides the reader with an insight into the complexity of any future generation's journey to the stars.