Razer does not supply drivers with the mouse instread you have to go to their website and download them http://www.razerzone.com/. The download of approx 34 mb is an easy to use installer that set up drivers and a utility to set options for the mouse. This utility takes very little system resouces and about 1612k memory .
When using the mouse I find first to fingers on each main button with third finger resting comfortably on the side best.
The 12 thumb bottons with the hand positoned are between the middle knuckle and the hand knuckle. This alows you with some geting adjustment to use the 12 thumb buttons either set to 1 to = on keyboard or set macros for them.
The mouse is very warm to use and with the default senstivity set to mid range is very resposive and quick and takes very little footprint to cover the screen.
Overall it is a very comfortable mouse to use and for any mmo fan will be a great additon to your computer.