The recent coronavirus pandemic proved that the time-old notion seems now truer than ever: that science and politics represent a clash of cultures. But why should scientists simply “stick to the facts” and leave politics to the politicians when the world seems to be falling down around us? Drawing on his experience as both a research scientist and an expert advisor at the centre of government, Ian Boyd takes an empirical approach to examining the current state of the relationship between science and politics. He argues that the way politicians and scientists work together today results in a science that is on tap for ideological (mis)use, and governance that fails to serve humanity’s most fundamental needs. Justice is unlikely—perhaps impossible—while science is not a fully integrated part of the systems for collective decision-making across society. In Science in Politics, Boyd presents an impassioned argument for a series of conceptual and structural innovations that could resolve this fundamental tension, revealing how a radical intermingling of these (apparently contradictory) professions might provide the world with better politics and better science.