The increasing demand for innovative techniques arises from the lack of safe, effective, and patient-friendly therapies for neurodegenerative disorders. With this objective in mind, the chapters of the book are structured to offer a thorough insight into recent advancements in utilizing the Zebrafish (ZF) as a model for studying Parkinson's disease (PD). This book aims to present readers with a comprehensive understanding of the clinical application of the ZF model in treating PD, encompassing the latest developments, challenges, safety considerations, toxicity issues, regulatory aspects, future potential, and limitations. Individuals in academia, the scientific community, business, and education seeking a more effective approach to target the brain stand to benefit from this resource. Key Features · Provides a comparative perspective of the Zebrafish-Parkinson’s Disease model · Highlights the restrictions of available medicines · Describes biochemical and histopathological characteristics, advantages and disadvantages of this model · Emphasizes distinct facets of histopathology · Presents advances and developments of the future potential perspectives