In 2007 AD, a virus sweeps across Europe. Many flee to the United States where they are held in quarantine camps. At the Boston camp, police officer Delon (Natasha Henstridge), hoping to leave with her son, has used black-market contacts to acquire a passport. Delon's partner is decapitated while they are investigating a killing, and another officer, Lemieux (Christopher Lambert) arrives with back-up. They move in on the killer, a psychotic who could infect the entire city within six hours.