This book gathers the proceedings of the International Conference on Information, Communication and Cybersecurity, held on November 10–11, 2021, in Khouribga, Morocco. The conference was jointly coorganized by The National School of Applied Sciences of Sultan Moulay Slimane University, Morocco, and Charles Darwin University, Australia. This book provides an opportunity to account for state-of-the-art works, future trends impacting information technology, communications, and cybersecurity, focusing on elucidating the challenges, opportunities, and inter-dependencies that are just around the corner. This book is helpful for students and researchers as well as practitioners. ICI2C 2021 was devoted to advances in smart information technologies, communication, and cybersecurity. It was considered a meeting point for researchers and practitioners to implement advanced information technologies into various industries.  There were 159 paper submissions from 24 countries. Each submission was reviewed by at least three chairs or PC members. We accepted 54 regular papers (34\%). Unfortunately, due to limitations of conference topics and edited volumes, the Program Committee was forced to reject some interesting papers, which did not satisfy these topics or publisher requirements. We would like to thank all authors and reviewers for their work and valuable contributions. The friendly and welcoming attitude of conference supporters and contributors made this event a success!