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Asbestos and Mesothelioma

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Description

This volume is comprised of a multidisciplinary assessment of the interplay between asbestos and cancer as well as new research about the biology and treatment of malignant mesothelioma.  Chapters on the various types of asbestos and other mineral fibers, epidemiology, history and future of asbestos-related diseases are included.  Other reviews present new information about the role of asbestos-related inflammation and genetic factors, including the role of inherited mutations of BAP1, in mesothelioma causation, as well as recent research about gene signatures, cell signaling, and epigenetic mechanisms in asbestos-related diseases.  Other chapters provide updates of novel disease biomarkers and prevention, mechanistic lesson from genetically engineered mouse and 3-D models of mesothelioma tumorigenesis and therapeutic resistance.  Also included are up-to-date reviews of surgical, molecularly targeted chemotherapeutic, and immunotherapeutic approaches for mesothelioma as well as an overview of legal issues.

Author Biography:

Joseph R. Testa, PhD, FACMG is Senior Member/Professor, Carol and Kenneth E. Weg Chair in Human Genetics, Chief of Laboratory Genetics, and Co-Leader of the Cancer Biology Program at Fox Chase Cancer Center, Philadelphia, PA. His research interests focus on mesothelioma pathogenesis and AKT-related oncogenesis. He has published numerous papers and reviews, and serves on the editorial boards of several journals, including as Senior Editor for Cancer Research. He has received multiple science awards, including the J. Christopher Wagner Medal from the International Mesothelioma Interest Group and the Pioneer Research Award from the Mesothelioma Applied Research Foundation. He is also a Fellow of the American Association for the Advancement of Science.
Release date Australia
August 8th, 2018
Audience
  • Professional & Vocational
Contributor
  • Edited by Joseph R. Testa
Edition
Softcover reprint of the original 1st ed. 2017
Illustrations
43 Illustrations, color; 22 Illustrations, black and white; VIII, 407 p. 65 illus., 43 illus. in color.
Pages
407
ISBN-13
9783319851839
Product ID
29199929

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