Excerpt from Biomedical Engineering and Instrumentation Branch, Division of Research Services, National Institutes of Health: Annual Report Fy 1989 A specific genetic strain of Corriedale sheep is used as an animal model for the study of liver pathophysiology, specifically, hyperbilirubinemia (dubin johnson Syndrome). This project is concerned with increasing the numbers of animals available for research by the controlled breeding of individuals which genetically transmit this character. This project is utilizing what is considered to be the only existing Corriedale sheep homozygotic for this trait. Efforts are being made to obtain both homozygous and heterozygous offspring from these highly inbred individuals. Semen collected artifically from the homozygotic rams was diluted in various cryoprotective extenders and then freeze preserved. This will ensure the long term availablity of male gametes for artifical insemination. Overall this project allows prepetuation of this specific gene pool-and ensures availability of research animal for future investigations of Dubin - Johnson Syndrome and related metabolic disorders.imcipal mves 16/00w and pram 9.0mm: (mow in. May musuguor.) (nam. Ave. Wane/y. Ma mun-i. Mum. About the Publisher Forgotten Books publishes hundreds of thousands of rare and classic books. Find more at www.forgottenbooks.com This book is a reproduction of an important historical work. Forgotten Books uses state-of-the-art technology to digitally reconstruct the work, preserving the original format whilst repairing imperfections present in the aged copy. In rare cases, an imperfection in the original, such as a blemish or missing page, may be replicated in our edition. We do, however, repair the vast majority of imperfections successfully; any imperfections that remain are intentionally left to preserve the state of such historical works.