Welcome to this book, where we delve into the intricate landscape of Chronic Myeloid Leukemia (CML). As you hold this text in your hands, you are not merely grasping a compilation of medical facts and figures, but rather embarking on a journey through the realms of science, human experience, and hope. Chronic Myeloid Leukemia, though formidable in its complexity, is not an insurmountable adversary. In these chapters, we aim to illuminate the path toward understanding, managing, and overcoming this disease. We navigate through the corridors of medical knowledge, exploring its origins, manifestations, and treatment modalities. Our journey begins with an Introduction, laying the foundation with a panoramic view of CML, its historical context, and the critical importance of early detection and intervention. From there, we dive deep into the molecular underpinnings of the disease, unraveling the intricate mechanisms that drive its progression. Clinical Presentation and Diagnosis emerge as pivotal waypoints, guiding both patients and healthcare professionals through the labyrinth of signs, symptoms, and diagnostic protocols. We explore the molecular landscape of CML, shedding light on the Philadelphia Chromosome and the BCR-ABL fusion gene, which lie at the heart of this condition. Treatment Modalities represent a beacon of hope amidst the darkness, showcasing the remarkable advances in targeted therapy, chemotherapy, and stem cell transplantation. Yet, we do not shy away from the challenges that accompany these treatments, addressing the adverse effects and the importance of supportive care. In the chapters that follow, we delve into the lived experience of CML, exploring the emotional, psychological, and practical dimensions of coping with the disease. But this book is not merely a repository of knowledge; it is a call to action. We examine the role of clinical trials and research in shaping the future of CML treatment, and we advocate for global collaboration and equity in access to care. As you navigate through these pages, I encourage you to approach this journey with an open mind and a hopeful heart. May this book serve as a guiding light in your quest for understanding, resilience, and healing. With warm regards, Dr. Bhratri Bhushan MD, DM