Doctor Cooper "Mackie" McKay's plans for a peaceful retirement are once again derailed when a man with flu-like symptoms passes out on a flight from London. Mackie calls on his surgical skills - and a dose of creativity - to save the young man's life. Instead of gratitude, however, he ignites the suspicions of the U.S. government. After masked military responders forcefully remove Mackie from the plane, he finds himself in the middle of an investigation by the Centers for Disease Control. As a deadly pathogen spreads through health centers across the U.S., Mackie learns that the most promising cure is embargoed by the FDA. He soon suspects domestic terrorism rooted in Big Pharma and sanctioned by public health officials. In the struggle for command and control of the outbreak, Mackie is caught in the cross-hairs of a governmental cover-up, where the only clear solution seems to be silencing the whistle blower.