A multidisciplinary and multifaceted approach is employed to identify principal ecosystems and natural resources in the US Great Plains that are at risk and that should receive priority for protection. The authors are drawn from a variety of disciplines and approaches, their ideas being presented as a pooling or harvest, rather than as a consensus. The 25 chapters provide background and in-depth discussion of multiple issues/problems related to Great Plains stewardship for future generations. The status and trends of major resources of the Great Plains within an historical, ecological and management framework are categorized according to common goals across the disciplines and can be used to make recommendations for public policy, research and development, and institutions. The challenge for residents of the Great Plains is to merge multiple ecosystem concepts to improve the environment and to improve economic vitality.