This volume presents an interdisciplinary reflection on the SARS-COV-2 pandemic and its consequences elaborated in real-time. It embodies the University of Palermo’s values and mission by bringing together academics of very diverse disciplinary fields on an issue that is disrupting all aspects of individual and community existence. This volume captures the voices of academics during the pandemic, allowing to crystallize the discourses that are emerging in a wide variety of scientific fields as events unfold and knowledge is rapidly evolving. They share the belief that to shed adequate light on the complex and multifaceted phenomenon of the COVID-19 pandemic and its consequences necessarily requires the adoption of an interdisciplinary approach, the consideration of a multiplicity of perspectives, and of a variety of levels of analysis. The organization of the single contributions in chapters allows the exchange of different perspectives, whilst conveying a general overall frameworkto the interpretation of the many facets of the changes and crisis generated by COVID-19. The volume addresses both academics and professionals dealing with the processes and the consequences brought forth by the pandemic and presents a solid example of the commitment an academic institution should devote to society and communities.