Non-Fiction Books:


TF Mediated Transcriptional Regulation in Plants
Click to share your rating 0 ratings (0.0/5.0 average) Thanks for your vote!


Paperback / softback
Crispr/Dcas9 by Baazim Hatoon
21% off
$69.99 was $88.99

Available on orders $100 to $1000 Learn more

Available from supplier

The item is brand new and in-stock with one of our preferred suppliers. The item will ship from the Mighty Ape warehouse within the timeframe shown below.

Usually ships in 10-14 days


Delivering to:

Estimated arrival:

  • Around 15-21 February using standard courier delivery


Developing targeted genome regulation approaches holds much promise for accelerating trait discovery and development in agricultural biotechnology. The type II CRISPR/Cas system has been adapted for genome editing and transcriptional modulation purposes across a variety of organisms. Here, we employed this system for targeted transcriptional regulation in planta by developing chimeric dCas9-based activators and repressors. By fusing activator and repressor domains to the C-terminus of dCas9, respectively, we generated transcriptional activators: dCas9.EDLL and dCas9.TAD, as well as transcriptional repressor: dCas9.SRDX. Our data demonstrate that the dCas9.EDLL and dCas9.TAD activators, guided by gRNAs complementary to promoter elements, induce strong transcriptional activation on episomal targets in plant cells. Moreover, our data suggest that the dCas9.SRDX repressor and the dCas9.EDLL and dCas9.TAD activators are capable of markedly repressing or activating, respectively, the transcription of an endogenous genomic target. Our data indicate that the CRISPR/dCas9: TFs DNA targeting system can be used in plants as a functional genomic tool and for biotechnological applications
Release date Australia
September 23rd, 2014
  • General (US: Trade)
Country of Publication
United States
black & white illustrations
Lap Lambert Academic Publishing
Product ID

Customer reviews

Nobody has reviewed this product yet. You could be the first!

Write a Review

Marketplace listings

There are no Marketplace listings available for this product currently.
Already own it? Create a free listing and pay just 9% commission when it sells!

Sell Yours Here

Help & options

Filed under...