This book offers a comprehensive approach to organizational excellence based on the author’s vast experience in managing excellence at highly innovative and dynamic organizations. It integrates various approaches into a consistent view of achieving excellence in the context of dynamic technological and societal developments. Starting from purpose and mission, it describes stakeholder mapping and analysis, and process and quality management. In turn, it sheds light on how to deal with business dynamics of various types and demonstrates how quantum-mechanical models can help to understand and manage dynamic organizational processes. The book then introduces readers to result measuring and performance management, followed by organizational learning and rewards and recognition. Moreover, it discusses (innovation) ecosystem leverage and organizational culture management as further important capabilities of excellent organizations. Best practices in corporate social responsibility and environmental, social and governance aspects are fully integrated throughout the book, which concludes by explaining how the UN Sustainable Development Goals can be applied to optimize business initiatives. The book is intended as a source of inspiration for managers working under highly dynamic organizational conditions, helping them take their businesses to higher levels. It also provides valuable industrial insights for scholars with an interest in organizational excellence.