Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

Name: Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy
SKU: 28342739
Price: 262.99 AUD
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Paperback / softback

Series:

Resistance to Targeted Anti-Cancer Therapeutics

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Description

This volume focuses on recent advances in understanding T cells as key players in antitumor immune responses, and as a result T cell-based immunotherapy is starting to transform the treatment of advanced cancers. However, despite recent successes, many patients with cancer fail to respond to these treatments. Defective migration of T cells into and within tumors is considered as an important resistance mechanism to cancer immunotherapy.The volume includes three sections. The first section covers general knowledge about T cell trafficking during a normal immune response but also during tumor development. The second section provides an in-depth description of the different obstacles that prevent T cells from migrating and contacting tumor cells. The third section explores therapeutic strategies to improve trafficking of T cells into tumors and, thus, to enhance the effectiveness of cancer immunotherapy.

Author Biography:

Emmanuel Donnadieu, Ph.D, is a researcher and team leader of the 'Dynamics of T cell Interactions' group at the Cochin Institute. His recent research include breakthroughs in newly developed methods for following the migration and activation patterns of lymphocytes and other immune cells within tumors.

Release date Australia

April 22nd, 2018

Audience

Professional & Vocational

Contributor

Edited by Emmanuel Donnadieu

Edition

Softcover reprint of the original 1st ed. 2016

Illustrations

19 Illustrations, color; 8 Illustrations, black and white; VIII, 199 p. 27 illus., 19 illus. in color.

Pages

199

Series

Resistance to Targeted Anti-Cancer Therapeutics

ISBN-13

9783319825281

Product ID

28342739

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Defects in T Cell Trafficking and Resistance to Cancer Immunotherapy

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