This updated and revised Second Edition provides a state-of-the-science review and clinical collection of research on treating depression with multiple therapies. The text is an essential guide for those who prescribe psychotropics or perform psychotherapy, including psychiatrists, residents, psychologists, and psychopharmacologists. Containing research data, case studies, and expert recommendations, this source explores the best acute, long-term, and combination treatment strategies for superior patient care. New to the Second Edition: a chapter devoted to a simultaneous discussion on psychotherapy and pharmacotherapy chapters on depression and anxiety, depression and pain, and new treatment options information on the advancements of genetics, imaging, and brain stimulation with regard to depressive disorders and implications for future use the latest research on drug development and combining drug treatments