This book presents new results and data for the 1969 Saint Vincent Cape Earthquake (Mw=7.8) and tsunami. It provides key information to access the Spanish Geophysical Data National Archive Compilation and includes data-sets that range from the Azores Islands to the Iberian Peninsula. On February 28th, 1969, a large earthquake (Mw=7.8) strokes the Iberian Peninsula and northern Morocco, producing some causalities and important damage and economic losses. In this Topical volume ten papers are published, which are representative of many contributions presented at a Workshop organized by the Universidad Complutense de Madrid (Spain) and the instituto Geográfico Nacional (Madrid, Spain) on the occasion of the 50th anniversary of the 1969 earthquake. These papers cover different aspects of communications presented at the Workshop. There are two papers dedicated to tsunamis, one to Earthquake Early Warning System, one paper on lithospheric structure, three on seismicity and adata archive, three focused on the 1969 earthquake, and one of the seismic hazard. Summarizing, this topical issue present new results on the structure, seismicity, seismotectonics, seismic hazard, and geodynamics of this complex region that extends from the Azores Islands to the Iberian Peninsula.