Enzymology at the Membrane Interface: Interfacial Enzymology and Protein-Membrane Binding

Name: Enzymology at the Membrane Interface: Interfacial Enzymology and Protein-Membrane Binding: Volume 583
SKU: 25846329
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Hardback

Series:

Methods in Enzymology

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Description

Enzymology at the Membrane Interface, the latest volume in the Methods in Enzymology series, covers a subset of enzymes that work in the environment of the biological cell membrane. This field, called interfacial enzymology, involves a special series of experimental approaches for the isolation and study of these enzymes.

Author Biography:

Michael H. Gelb studied chemistry and biochemistry as an undergraduate at the University of California at Davis. His Ph.D. studies with Stephen G. Sligar at Yale University led to a better understanding of the catalytic mechanism of cytochrome P450. As an American Cancer Society Postdoctoral Fellow in the laboratory of the late Robert H. Abeles at Brandeis University, Gelb studied a variety of mechanism-based inactivators of serine proteases and developed fluorinated ketones as tight-binding inhibitors of several classes of proteases. In 1985 Gelb became a faculty member in the Departments of Chemistry and Biochemistry at the University of Washington. Major breakthroughs in the group include the development of methods to properly analyze the action of enzymes on membrane surfaces, the discovery of protein prenylation (farnesylation and geranylgeranylation) in mammalian cells (together with John A. Glomset), the development of Isotope-Coded Affinity Tags (ICAT reagents) for proteomic applications (together with Ruedi Aebersold), and the development of newborn screening for lysosomal storage diseases by mass spectrometry.

Release date Australia

January 13th, 2017

Audience

Professional & Vocational

Contributor

Volume editor Michael H. Gelb

Pages

430

Series

Methods in Enzymology

ISBN-13

9780128094198

Product ID

25846329

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